Medsol RX review
Month-to-month semaglutide is $199 after a $169 first month, and three prepaid plans trade the whole term up front for a lower monthly figure.
The verdict
Medsol RX prices compounded semaglutide at $199 a month and tirzepatide at $259 once the first month has passed, and it prints the first month, the standing rate and every prepaid plan together in one table. A buyer can see the whole price structure before the intake begins, which is more than the page reveals about dose.
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- Category
- GLP-1 telehealth
- Molecule
- Semaglutide · Tirzepatide
- Form
- Injection
- States
- 50
- From
- From $199/mo
- Dose published
- No
- Prescription
- Required
- Compounded
- Yes — not FDA-approved
- Pharmacy
- Not named
- LegitScript
- Claimed by provider
Medsol RX sells compounded semaglutide and tirzepatide by weekly injection, along with an oral semaglutide, lower-dose microdose options and branded pens, and it bundles one-on-one care coaching into every weight-loss plan it lists.
Who writes the prescription, and what do they see?
The footer names the clinicians: final prescribing decisions are made by Open Loop's licensed U.S. clinicians after a telehealth consultation and a review of the patient's medical history. The site's own assessment, it says, only screens for initial eligibility and does not establish a doctor-patient relationship, so the clinical relationship begins with that network rather than with Medsol itself.
Each plan card lists the same four inclusions, an injection supply, a dedicated care coach, a custom treatment plan and medical oversight, with priority check-ins added on the six-month and twelve-month plans. The coach is the distinctive piece here, written into the price on every card rather than sold as an add-on after the prescription arrives.
What happens when the dose goes up?
Nothing on the packages page ties a figure to a dose, and no milligram amounts are printed beside any plan, so whether the $199 holds as a patient climbs from the starting dose is not stated. The month-to-month table shows that same figure from the second month through the fifth and beyond, which reads as flat, though the page never says so in words.
What the price includes
A buyer paying month to month spends $169 on semaglutide in the first month and $199 in each month after, and the page says that buyer can switch to a plan at any point. The three longer plans lower the monthly figure in exchange for paying the whole term up front, down to $129 a month on twelve months, and tirzepatide follows the same pattern from a $239 first month to its standing $259.
What it claims, and what it cites
Both injectable lines are compounded by certified U.S. pharmacies that the site describes as operating in FDA-regulated facilities, though none of those pharmacies is named on the packages page. The same footer states plainly that compounded medications are not FDA-approved and have not been evaluated by the FDA for safety, efficacy or quality. Branded Ozempic and Zepbound pens are sold separately, with coaching included, for a buyer who wants the approved product instead of a compounded one.
Where it holds up, and where it does not
- Strength: First month, standing rate and plans in one table
- Strength: Care coaching included on every plan
- Strength: The prescribing clinician network is named
- Strength: Switching to a plan is allowed anytime
- Limitation: No milligram dose beside any figure
- Limitation: Lower rates require paying the term up front
- Limitation: Dose-linked price changes are never addressed
- Limitation: Dispensing pharmacies are described, not named
What the evidence says about this kind of treatment
The assessment above is about Medsol RX. These are about the drugs it sells, and they are traced to the primary literature.
- Right for
- A reader who wants coaching bundled into the price and can weigh a month-to-month rate against prepaid plans laid out on one page.
- Wrong for
- A reader who needs dose-by-dose pricing before starting treatment, since the packages page prints no milligram amounts at all.
The evidence behind what Medsol RX prescribes
These studies examine the medicines, not this provider. Results with approved products do not establish the quality or effectiveness of a seller’s compounded formulation.
- Cochrane Review of Semaglutide for Obesity: 18 Trials Graded
A 2025 Cochrane review pooled eighteen randomized trials. The weight figure is high certainty and smaller than the marketing, and almost everything else is graded lower.
- Tirzepatide vs Semaglutide: Which Works Better for Weight Loss?
In a 72-week randomized trial at weight-management doses, weight fell 20.2 percent on tirzepatide and 13.7 percent on semaglutide. Routine-care studies found a smaller gap, three to four points.
How Medsol RX compares
| Seller | Who it suits | Go |
|---|---|---|
 Belle Health | Someone who wants included nutrition and clinical support and can choose an appropriate supply commitment after discussing treatment. | See Belle Health → |
 YourEra | Readers committing six months who have read which figure belongs to which plan | See YourEra → |
 Clume Health | Readers who want both molecules at one rate and will re-check the figure before paying | See Clume Health → |
More GLP-1 telehealth sellers reviews: BrightmedsCabanaCaliberRxCalibrate HealthCalifornia Trim ClinicCall-On-Doc
Sponsored alternative
SkinnyRx
Readers choosing tirzepatide, the one line with a published standing rate
Check SkinnyRx availability →Frequently asked
- What does the first month cost?
- $169 for semaglutide and $239 for tirzepatide on the month-to-month path, after which the packages page lists $199 and $259 a month for every month that follows.
- Who writes the prescription?
- Clinicians in Open Loop's licensed U.S. network, after a telehealth consultation, according to the footer, which also describes the site's own questionnaire as an initial eligibility screen and nothing more.
- Is Medsol RX LegitScript certified?
- The packages page displays a LegitScript Approved badge beside its financing and shipping notes, which is the seller's own statement of that certification.
- Is Medsol RX expensive compared with other GLP-1 telehealth sellers?
- Medsol RX publishes a starting figure of $199/mo. Across the 402 GLP-1 telehealth sellers we review that publish a single monthly figure, those run $49 to $525.42 with a median of $190, which puts Medsol RX above the median. The other 178 GLP-1 telehealth sellers we review quote only after an intake or price by dose, so they are not in that comparison. A starting figure is not a bill — labs, consultations and shipping are often charged separately, so confirm what your own quote includes.