Enhance MD review
Everything here is billed in four-week cycles, so a plan advertised by the month lands thirteen times a year rather than twelve.
The verdict
Enhance MD charges $249 for a one-month plan of compounded semaglutide and $329 for full-dose compounded tirzepatide, each billed every four weeks. Thirteen charges land in a calendar year, so those are $270 and $356 a calendar month.
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- Category
- GLP-1 telehealth
- Molecule
- Semaglutide · Tirzepatide
- Form
- Injection
- Dose pricing
- Flat across doses
- States
- 39
- From
- From $270/mo
- Prescription
- Required
- Compounded
- Yes — not FDA-approved
- Labs
- Included
Enhance MD sells compounded semaglutide and compounded tirzepatide as weekly injections across thirty-nine states, and the thing a reader has to hold on to is that its cycle is four weeks rather than a calendar month. The semaglutide plan ladder runs $249 month to month, $237 at three months, $224 at six and $212 at twelve. Labs, the consultation and two-day shipping are described as included at every rung.
Who writes the prescription, and what do they see?
Labs and a consultation sit inside the price rather than beside it, which is the shape a reader should want and the shape that makes a like-for-like comparison hard. A seller charging less and billing the consultation separately can look cheaper on a landing page and cost more across a year. How often the consultation repeats, and whether labs are drawn again after the first set, is not something the priced row establishes.
Treatment is arranged remotely and the medication arrives on a four-week rhythm, which sounds like a monthly subscription and is not one. Thirteen deliveries land in a calendar year rather than twelve, so the advertised figure understates the annual cost by roughly one fill. The first order carries a discount, larger on the twelve-month plan, which is also the point at which a reader commits to the term.
What happens when the dose goes up?
The semaglutide plan is flat at all doses, so an escalation does not move the bill, and that is worth more across a year than most of the headline gaps between sellers. Tirzepatide comes in two products: the full-dose GLP-1 Advanced plan this site ranks, and a separate low-dose microdosing tier sold only on three, six and twelve-month prepay terms.
What the price includes
The twelve-month rung is the figure the page leads with, at $212, and it buys a forty-eight-week term rather than a calendar year. The one-month plan is $249 per four-week fill, which is $270 a calendar month once thirteen fills are counted. Full-dose tirzepatide is $329 per fill on the same one-month plan, or $356 a calendar month.
What it claims, and what it cites
Both products are compounded, so a pharmacy prepares them and no regulator reviews the finished vial before it ships. The published results for tirzepatide came from the approved label doses over seventy-two weeks. The microdosing tier sits below those doses, which is why this site prices the full-dose plan instead.
Where it holds up, and where it does not
- Strength: Labs and consultation inside the price
- Strength: Semaglutide rate flat at every dose
- Strength: Whole plan ladder published on one page
- Limitation: Cycle is four weeks, not a month
- Limitation: The lead figure needs a forty-eight-week term
- Limitation: Microdose tier is prepay only
What the evidence says about this kind of treatment
The assessment above is about Enhance MD. These are about the drugs it sells, and they are traced to the primary literature.
- Right for
- A reader who wants the labs and the consultation inside one figure, and who can hold the four-week cycle in mind when comparing it with a monthly rate elsewhere.
- Wrong for
- A reader comparing the advertised $212 against another seller's month-to-month rate, because it is the twelve-month rung of a four-week cycle.
The evidence behind what Enhance MD prescribes
These studies examine the medicines, not this provider. Results with approved products do not establish the quality or effectiveness of a seller’s compounded formulation.
- Cochrane Review of Semaglutide for Obesity: 18 Trials Graded
A 2025 Cochrane review pooled eighteen randomized trials. The weight figure is high certainty and smaller than the marketing, and almost everything else is graded lower.
- Tirzepatide vs Semaglutide: Which Works Better for Weight Loss?
In a 72-week randomized trial at weight-management doses, weight fell 20.2 percent on tirzepatide and 13.7 percent on semaglutide. Routine-care studies found a smaller gap, three to four points.
How Enhance MD compares
| Seller | Who it suits | Go |
|---|---|---|
 Belle Health | Someone who wants included nutrition and clinical support and can choose an appropriate supply commitment after discussing treatment. | See Belle Health → |
 Pallas Health | A reader past the opening quarter who wants check-ins priced in, not billed per visit. | See Pallas Health → |
 Idgie Health | A reader who wants a seller to say plainly that a microdose is an off-label use before taking a payment for one. | See Idgie Health → |
More GLP-1 telehealth sellers reviews: Joey MedJoi + BlokesJRNYSJumpstartMDJune HealthJustAnswer Weight Loss
Sponsored alternative
SkinnyRx
Readers choosing tirzepatide, the one line with a published standing rate
Check SkinnyRx availability →Frequently asked
- Why does this site show $270 rather than the advertised $212?
- Two reasons. $212 is the twelve-month rung, and a one-month plan is $249. And the plan bills every four weeks, so thirteen charges land in a calendar year: $249 a fill is $269.75 a calendar month.
- What does the price include?
- Labs, the consultation and two-day shipping are described as included at every rung of the semaglutide plan. That is worth holding on to when comparing it with a seller that bills a consultation separately.
- Can the microdosing tirzepatide plan be bought monthly?
- No. The low-dose tier is sold on three, six and twelve-month prepay terms only. The full-dose tirzepatide plan does offer a one-month option, at $329 per four-week fill.
- Is Enhance MD expensive compared with other GLP-1 telehealth sellers?
- Enhance MD publishes a starting figure of $270/mo. Across the 402 GLP-1 telehealth sellers we review that publish a single monthly figure, those run $49 to $525.42 with a median of $190, which puts Enhance MD above the median. The other 178 GLP-1 telehealth sellers we review quote only after an intake or price by dose, so they are not in that comparison. A starting figure is not a bill — labs, consultations and shipping are often charged separately, so confirm what your own quote includes.